Is recurrence free survival same as disease-free survival?

Is recurrence free survival same as disease-free survival?

In cancer, the length of time after primary treatment for a cancer ends that the patient survives without any signs or symptoms of that cancer. In a clinical trial, measuring the relapse-free survival is one way to see how well a new treatment works. Also called DFS, disease-free survival, and RFS.

What is the difference between PFS and EFS?

PFS progression-free survival; EFS event-free survival; OS overall survival; RCTs randomized controlled trials; HR hazard ratio; CI confidence interval.

What is the difference between OS and PFS?

In some trials, researchers set out to look at progression-free survival (PFS), a measure of how long someone is on a treatment before their cancer starts to grow. They can also look at overall survival (OS), or how long someone lives after starting on a treatment.

What is the difference between PFS and DFS?

Disease-Free Survival (DFS), also known as Relapse-Free Survival (RFS), is often used as a primary endpoint in phase III trials of adjuvant therapy. Progression-Free Survival (PFS) is used commonly as a primary endpoint in phase III trials evaluating treatment of metastatic cancer.

Is TTP the same as PFS?

Time to progression (TTP) does not count patients who die from other causes but is otherwise a close equivalent to PFS (unless there are many such events). The FDA gives separate definitions and prefers PFS.

What is EFS in AML?

Event-free survival was defined by: • Creutzig et al. (227) in a study of AML, defined EFS as early death, resistant leukemia, relapse, secondary malignancy, or death resulting from any cause.

What is EFS in clinical trials?

The measure of time after treatment that a group of people in a clinical trial has not had cancer come back or get worse. This term is also usually used in the context of scientific research.

Is PFS better than OS?

Among the comparisons that demonstrated inconsistent results between PFS and OS, the magnitude of inconsistency was relatively low. Among the 39 showing improvement in PFS but not OS, the average PFS benefit was 1.5 months (standard deviation [SD] = 1.4), and the average decline in OS was -1.4 months (SD=1.6).

Is overall survival a surrogate endpoint?

Background. Progression-free survival (PFS) is a surrogate endpoint widely used for overall survival (OS) in oncology. Validation of PFS as a surrogate must be done for each indication and each intervention.

How do you define overall survival?

Listen to pronunciation. (oh-ver-AWL ser-VY-vul) The length of time from either the date of diagnosis or the start of treatment for a disease, such as cancer, that patients diagnosed with the disease are still alive.

How to calculate overall survival?

– Patients are randomly assigned to different treatment arms; – All patients do not enter the study at the same time; – Patients drop out of or are lost from the study at different time intervals after entering the study; and – The outcome variable of interest may or may not occur during the study observation period (Rich et al., 2010).

What is disease free survival?

Study Rundown: Kawasaki disease (KD) is an idiopathic acute systemic vasculitis that occurs in young children. When left untreated, it causes coronary artery aneurysms (CAAs) in about 25% of cases, and is therefore an important cause of chronic, acquired cardiac disease.

What is the definition of overall survival?

Overall survival refers to the fact that the patient has not died from any cause. Thus, in a clinical trial the measure of overall survival would compare the number of patients who had died and the number who had not died. Progression free survival refers to survival without progression of the disease.

What is overall survival?

overall survival (oh-ver-AWL ser-VY-vul) The length of time from either the date of diagnosis or the start of treatment for a disease, such as cancer, that patients diagnosed with the disease are still alive. In a clinical trial, measuring the overall survival is one way to see how well a new treatment works.