Does micronization increase surface area?

Does micronization increase surface area?

Micronization of poorly water soluble drugs leads to increased absolute surface area but the effective surface area required for wetting is less which leads to flotation as could be observed from dry milling (Rasenack et al., 2004).

What is micronized powder?

A micronized substance is reduced to a fine powder, the particles of which are measured in microns (= a unit of length equal to 106 meter) in diameter. This is a micronized powder with a particle size of 5 microns. Micronized substances, with particles smaller than 20 micron, have greater solubility.

What is a micronizing mill?

Feb 06, 2012. The McCrone micronizing mill is an effective means of reducing sample to sub-micron sizes suitable for x-ray diffraction; x-ray fluorescence; infra-red spectroscopy; and atomic absorption analysis.

What is Preformulation?

Preformulation is the stage of development during which the physicochemical properties of the drug substance are characterised and established. Knowledge of the relevant physiochemical and biopharmaceutical properties determines the appropriate formulation and delivery method for Pre-Clinical and Phase 1 studies.

What is meant by micronization?

: to pulverize especially into particles a few micrometers in diameter.

What is micronization API?

Micronization is a process for reducing the diameter of a solid material’s particles to enable the solubility of Active Pharmaceutical Ingredients (APIs). Whether administered orally or topically, this solubility is a key factor in bioavailability, and ultimately, the effectiveness of a drug.

What is the purpose of micronization?

Micronization is most often used to describe processes that reduce particle size by using fluid energy, such as a jet mill, rather than by mechanical means. Mechanical particle-size reduction using a bead mill, however, can also be used to obtain micrometer- and nanometer-sized particles.

What is Preformulation test?

Preformulation testing involved investigation of physical and chemical properties of a drug substance alone and when combined with excipients. It was the first step in the rational development of dosage forms.