What is Chlorobutanol Hemihydrate?

What is Chlorobutanol Hemihydrate?

Name Chlorobutanol hemihydrate Drug Entry Chlorobutanol. Chlorobutanol, or chlorbutol, is an alcohol-based preservative with no surfactant activity 5. It also elicits sedative-hypnotic and weak local anesthetic actions in addition to antibacterial and antifungal properties.

What is Chlorobutanol used for?

Chlorobutanol is a common detergent preservative in eye drops and other ophthalmic therapeutic formulations. Chlorobutanol is a tertiary alcohol. A colorless to white crystalline compound with a camphoraceous odor and taste. It is a widely used preservative in various pharmaceutical solutions, especially injectables.

What is Chlorobutanol anhydrous?

Chlorobutanol, Anhydrous, NF, 98-100.5%, Spectrum™ Chemical Spectrum™ Chemical Chlorobutanol, Anhydrous, NF is a very effective preservative in many pharmaceutical products for eyes, ears and nose, dental preparations. The anhydrous form is useful in formulations where the absence of water is desired.

What is the reaction involved in Chlorobutanol?

Similar in nature to chloral hydrate, it is formed by the simple nucleophilic addition of chloroform and acetone. As a long-term stabilizer of multi-ingredient preparations, chlorobutanol is normally used at a concentration of 0.5%. At this concentration, it also conserves its antimicrobial activity.

What catalyst is used in chlorobutanol?

Chlorobutanol (1) is prepared by addition of chloroform to acetone under the catalytic influence of powdered potassium hydroxide 1. I1/ has a local anesthetic potency to a mild degree and is used as an anesthetic dusting powder.

How do you make chlorobutanol?

It is prepared from acetone and chloroform using KOH to give chlorobutanol. Chlorbutanol is formed by the simple nucleophilic addition of chloroform and acetone, this reaction is base driven by potassium or sodium hydroxide.

Is chlorobutanol poisonous?

Although chlorobutanol is available in a large number of preparations, the incidence of toxicity appears to be low. However, with continued exposure to high-dose chlorobutanol, significant toxicity may occur. It seems prudent to use caution in the continued administration of products containing chlorobutanol.

Is chlorobutanol basic or acidic?

Acid dissociation constants calculated using MoKa v3.0.0

What is the molecular weight of Chlorobutanol?

175.5 g/molChlorobutanol / Molar mass

What type of compound is acetone?

organic compound
Acetone, propanone or dimethyl ketone, is an organic compound with the formula (CH3)2CO. It is the simplest and smallest ketone. It is a colourless, highly volatile and flammable liquid with a characteristic pungent odour.

Is chlorobutanol a sedative?

Chlorobutanol (trichloro-2-methyl-2-propanol) is a preservative, sedative, hypnotic and weak local anesthetic similar in nature to chloral hydrate.