What is Osler nodes and Janeway lesions?

What is Osler nodes and Janeway lesions?

Osler nodes and Janeway lesions are cutaneous manifestations of endocarditis, a disease most commonly arising from a bacterial or fungal infection of the cardiac endocardium.[1] Osler nodes are tender, purple-pink nodules with a pale center and an average diameter of 1 to 1.5 mm.[2] They are generally found on the …

What are Osler nodes indicative of?

Osler’s nodes result from the deposition of immune complexes. The resulting inflammatory response leads to swelling, redness, and pain that characterize these lesions. The nodes are commonly indicative of subacute bacterial endocarditis.

What do Osler nodes look like?

Osler nodes are red-purple, slightly raised, tender lumps, often with a pale centre. Pain often precedes the development of the visible lesion by up to 24 hours. They are typically found on the fingers and/or toes.

Where are Osler nodes?

Osler nodes (Figure A and B ) are purplish-colored papules found over the peripheries. They are tender to touch and pathognomonic of infective endocarditis. They are differentiated from Janeway lesions such that the latter are nontender.

Where are Janeway lesions located?

Janeway lesions are irregular, nontender hemorrhagic macules located on the palms, soles, thenar and hypothenar eminences of the hands, and plantar surfaces of the toes. They typically last for days to weeks. They are usually seen with the acute form of bacterial endocarditis.

What does a Janeway lesion look like?

Overview. Janeway lesions are seen in people with acute bacterial endocarditis. They appear as flat, painless, red to bluish-red spots on the palms and soles.

Where are Janeway lesions seen?

What is the difference between Janeway’s and Osler’s lesions?

The only distinguishing features between the two lesions seem to be the pain and suppuration that occur with an Osler’s node and not with a Janeway’s lesion. Other criteria, such as color, nodularity, size, location, and duration, are variable.

What is the difference between Janeway and Osler nodes?

In contrast to Osler nodes, Janeway lesions are non-tender, often haemorrhagic (bleeding into the skin), and occur mostly on the palms and soles on the thenar and hypothenar eminences (at the base of the thumb and little finger respectively). They tend to last days to weeks before healing totally.

What are Osler nodes and Janeway lesions in endocarditis?

Osler nodes and Janeway lesions are two rare but well-known skin manifestations of bacterial endocarditis. They have also rarely been described in systemic lupus erythematosus (SLE), gonococcaemia (gonorrhoea), haemolytic anaemia and typhoid fever. They are important as they may help in the earlier diagnosis of a serious medical disorder.

What is the difference between Osler’s node and Osler’s nodule?

While there be no difference histologically since both may be evidence of a vasculitis, there is a striking difference in the clinical presentation of these lesions. Clinically the Osler’s node is a painful, tender bluish-purple nodular lesion situated in the terminal phalanges of the finger or toes.