What antibiotics are used to treat Q fever?

What antibiotics are used to treat Q fever?

Most people who are sick with Q fever will recover without antibiotic treatment. However, for people who develop Q fever disease, treatment with 2 weeks of doxycycline antibiotic is recommended.

How is Coxiella treated?

The best treatment is a combination of doxycycline and hydroxychlorquine. Hydroxychloroquine has no activity against C. burnetii, but it alkalinizes the phagolysosome, thereby rendering doxycylince bactericidal against C. burnetii.

What is Q fever endocarditis?

Endocarditis is the most common presentation of chronic Q fever, a zoonosis caused by the obligate intracellular bacteria Coxiella burnetii. Commonly believed to be a rare disorder, it has been estimated to account for up to 5% of all endocarditis cases worldwide (1–3).

How long does it take to get rid of Q fever?

Q fever is treated with the antibiotic doxycycline. How long you take the medicine depends on whether or not you have acute or chronic Q fever. For acute infections, antibiotic treatment lasts two to three weeks. People who have chronic Q fever usually must take a combination of antibiotics for at least 18 months.

Who should not take doxycycline?

Doxycycline should not be used in children under 8 years of age except for inhalational anthrax, Rocky Mountain spotted fever, or if your doctor decides it is needed.

Does combination therapy improve outcomes of Q fever endocarditis?

Examination of Q fever endocarditis outcomes in France from 1983 to 2006 shows that use of the combination therapy has coincided with reduced mortality and a reduced need for heart valve replacement [28].

What is the empiric treatment for acute Q fever (Q fever)?

Gikas A, Kofteridis DP, Manios A, Pediaditis J, Tselentis Y. Newer macrolides as empiric treatment for acute Q fever infection. Antimicrobial agents and chemotherapy. 2001;45(12):3644–3646.

How long should doxycycline and hydroxychloroquine be prescribed for Q fever endocarditis?

Prescription of the doxycycline and hydroxychloroquine combination for at least 18 months allows shortening of the duration of therapy and reduction in the number of relapses. Treatment of Q fever endocarditis: comparison of 2 regimens containing doxycycline and ofloxacin or hydroxychloroquine Arch Intern Med.

What is the most common abnormality found by echocardiography in Q fever endocarditis?

In a retrospective study of patients with Q fever endocarditis, the most common abnormality found by echocardiography in patients with chronic Q fever endocarditis was a newly discovered or worsening valvular insufficiency ( 97 ).