Which drug contains emetine?

Which drug contains emetine?

Emetine is the active ingredient in ipecac syrup, a preparation which was frequently used at one time to induce emesis in many acute oral poisonings. Abuse of ipecac by people with bulimia can lead to cardiac toxicity.

What does emetine meaning?

emetine in British English (ˈɛməˌtiːn , -tɪn ) or emetin (ˈɛmətɪn ) noun. a white bitter poisonous alkaloid obtained from ipecacuanha: the hydrochloride is used to treat amoebic infections. Formula: C29 H40 O4N2. Collins English Dictionary.

What is emetine obtained from?

Emetine (1) is a natural product alkaloid native to Brazil (Fig. 1). Emetine and its analogs occur in three plant families including Alangiaceae, Icacinaceae, and Rubiaceae. One major source of emetine and its analogs is Psychotria ipe- cacuanha Stokes (Rubiaceae).

Which reagent is used to indicate the presence of emetine?

Answer: Cephaeline. Explanation: Cephaeline is a desmethyl analog of emetine also found in ipecac root.

Why is emetine toxic?

emetine is known to have cardiac toxicity, and since our in vivo experiments demonstrate that emetine is as potent an inhibitor of leucine incorporation into cardiac proteins as cycloheximide, it is likely that the production of toxicity depends on interference with myo- cardial protein synthesis.

What is emetine cardiotoxicity?

Emetine in ipecac syrup is the first aid treatment of choice for many acute toxic oral ingestions and the alkaloid, itself, is used to treat amebiasis. Cardiotoxicity occurs following chronic exposure, such as occurs therapeutically in amebiasis and with ipecac abuse by bulemics.

What is emetine injection?

Emetine is used for the treatment of amebiasis and is a component of ipecac syrup. Emetine is both myotoxic and cardiotoxic. It has been shown to cause mitochondrial and myofibrillar change that can lead to myofiber necrosis. CK is usually elevated but can be normal in some patients with emetine-induced myopathy.

Is alcohol a Cardiotoxin?

Alcohol and its metabolite, acetaldehyde, are cardiotoxins. Myocardial depression is initially reversible but, if alcohol consumption is sustained, can lead to myocyte vacuolization, mitochondrial abnormalities, and myocardial fibrosis.

Why was ipecac discontinued?

Discontinuation. Ipecac has been found to have minimal health benefits, and is ultimately ineffective at purging the body of poisonous substances. It was initially discontinued due to production costs and lack of raw materials.

Is ipecac the same as ipecacuanha?

Ipecac also is known as ipecacuanha, golden root, Rio ipecac or Brazilian ipecac, Matto Grosso ipecac, and Costa Rica ipecac.