Do quinolones cause tendon rupture?

Do quinolones cause tendon rupture?

Approximately 2% to 6% of all Achilles tendon ruptures in people older than 60 years can be attributed to quinolones. Conclusions Current exposure to quinolones increased the risk of Achilles tendon rupture. The risk is highest among elderly patients who were concomitantly treated with corticosteroids.

Do all fluoroquinolones cause tendon rupture?

“In our study, fluoroquinolones as a class were not associated with the increased risk of tendon ruptures,” the researchers point out. “Neither ciprofloxacin nor moxifloxacin exhibited any risk for tendon ruptures.

Which antibiotics weaken tendons?

The new warnings apply to fluoroquinolones, a class of antibiotics that includes the popular drug Cipro. The FDA has told companies that the drugs must now carry “black box” warnings alerting doctors and patients that the drugs can increase risk of tendinitis and tendon rupture in some patients.

How common is tendonitis with ciprofloxacin?

In the general population, the estimated occurrence rate of fluoroquinolone-induced tendinopathy is from 0.14% to 0.4%. Fluoroquinolone-induced tendinopathy most commonly involves weight-bearing tendons.

Is tendon damage from Levaquin permanent?

Fluoroquinolone medicines (which contain ciprofloxacin, levofloxacin, lomefloxacin, moxifloxacin, norfloxacin, ofloxacin, pefloxacin, prulifloxacin and rufloxacin) can cause long-lasting, disabling and potentially permanent side effects involving tendons, muscles, joints and the nervous system.

How do fluoroquinolones affect tendons?

The most common presenting symptom of fluoroquinolone-associated tendinopathy is pain. This pain is usually of a sudden onset and may be accompanied by acute signs of inflammation and swelling. Achilles tendon rupture may be preceded by pain,25,26 but half of tendon ruptures have been reported to occur without warning.

How long after taking Levaquin can tendon rupture occur?

Tendon damage (especially to Achilles tendon but also other tendons) can occur within 48 hours of starting fluoroquinolone treatment but the damage may be delayed several months after stopping treatment.

What medications affect tendons?

Tendon injury belongs to the less known side effects of some drugs, reported until recently only for glucocorticoids and fluoroquinolones. To date, some other classes of drugs such as statins, aromatase inhibitors, anabolic steroids, potentially causing tendon injury, have been added to the list.

Can amoxicillin cause Achilles tendonitis?

The Achilles tendon seems to be the most commonly affected by the use of these antibiotics, but it can involve any of the tendons in your body. It affects both young and old people with reported ages ranging between 18 to 91 years.

Does Cipro cause permanent tendon damage?

How long after taking Cipro can tendon rupture occur?

The mean latency period between the start of FQ treatment and occurrence of tendinopathy has been reported to be a few hours to months, with a median onset of 6 days. In one report, half of tendon ruptures occurred within one week of FQ administration, with symptoms starting within two hours in one patient.

How do I know if my tendon is torn?

Ruptured Tendon Symptoms

1. A snap or pop you hear or feel.
2. Severe pain.
3. Rapid or immediate bruising.
4. Marked weakness.
5. Inability to use the affected arm or leg.
6. Inability to move the area involved.
7. Inability to bear weight.
8. Deformity of the area.