Does Precedex decrease cardiac output?

Does Precedex decrease cardiac output?

Dexmedetomidine significantly decreases cardiac output (by approximately 40%).

What does dexmedetomidine do to the heart?

The administration of a bolus of 1 μg/kg dexmedetomidine initially results in a transient increase of the blood pressure and a reflex decrease in heart rate, especially in younger, healthy patients (16).

How does Precedex affect the heart?

Patients who receive dexmedetomidine and develop a greater than 30% decrease in heart rate may be at high risk for severe bradycardia leading to pulseless electrical activity. We urge caution when using dexmedetomidine, especially in patients with significant cardiac disease.

What are the indications for Precedex?

1 INDICATIONS AND USAGE Precedex is indicated for sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care setting. Precedex should be administered by continuous infusion not to exceed 24 hours.

What is the difference between propofol and precedex?

Precedex and propofol are different types of sedatives. Precedex is an alpha2-adrenergic agonist and propofol is a sedative-hypnotic.

What is the advantage of precedex vs propofol?

Conclusions: For ICU patient sedation, dexmedetomidine may offer advantages over propofol in terms of decrease in the length of ICU stay and the risk of delirium. However, transient hypertension may occur when dexmedetomidine is administered with a loading dose or at high infusion rates.

Why is dexmedetomidine better than clonidine?

Dexmedetomidine is 8 times more specific for α2 receptors than clonidine and the improved specificity for the α2 adrenoreceptors, especially for the 2A subtype may make it to be a much more effective sedative than clonidine.

When should you not use Precedex?

However, it should be used cautiously in patients with bradycardia and hypotension as the medication may exacerbate these findings. Additionally, it should be used cautiously in patients with known heart failure as there is level B evidence showing dexmedetomidine can potentially exacerbate myocardial dysfunction.

Can Precedex cause tachycardia?

Common side effects of Precedex include: bradycardia, hypotension, agitation, hypertension, nausea, and tachycardia.

What is the difference between propofol and Precedex?

How does Precedex affect blood pressure?

Dexmedetomidine administered in high concentrations may cause systemic and pulmonary hypertension because of direct peripheral vascular effects or may compromise myocardial function and blood pressure.

Why is Precedex preferred over propofol?

What is Precedex used to administer?

PrecedexTM is indicated for sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care setting. Precedex should be administered by continuous infusion not to exceed 24 hours.

What is the indication of Precedex for pediatric patients?

pediatric patients. Precedex was first approved in 1999 and is indicated for intensive care unit (intubated and mechanically ventilated patients) and procedural sedation (non-intubated patients) in adults. There is no approved indication for pediatrics.

Does Precedex cause serious outcome and drug usage data?

for Children Act (BPCA) and Pediatric Research Equity Act (PREA), the Office of Surveillance and Epidemiology (OSE) evaluated post-marketing adverse event reports with a serious outcome and drug utilization data for Precedex (dexmedetomidine HCl injection, referred to as “DEX” in this review) in

When was Precedex approved by the FDA?

Precedex (dexmedetomidine HCl injection) Pediatric Labeling Approval Date: April 26, 2013 Application Type/Number: NDA 021038 Applicant/Sponsor: Hospira OSE RCM #: 2015-2044 **This document contains proprietary drug use data obtained by FDA under contract. The