How do you calculate allele frequency of a blood group?

How do you calculate allele frequency of a blood group?

Based on this formula, the allele frequencies of the ABO blood groups in the population was as follows: the frequency of the Io allele (r) = 0.6052 the frequency of the Ia allele (p) = 0.2607 and the frequency of the Ib allele (q) = 0.134.

How many alleles determine ABO blood type?

three alleles
For example, the ABO blood group system has three alleles that affect the expression of antigens on the surface of red blood cells: alleles A, B, and O. Both alleles A and B are expressed in individuals with the AB blood type.

How many alleles does ABO gene have?

ABO blood group The ABO gene is located on chromosome 9 and has three alleles, A, B and O.

How do you know if you’re an AA or AO?

If someone has blood type A, they must have at least one copy of the A allele, but they could have two copies. Their genotype is either AA or AO. Similarly, someone who is blood type B could have a genotype of either BB or BO. A blood test of either type AB or type O is more informative.

Is controlled by three alleles ABO?

The four main blood groups A, B, AB, and O are controlled by three alleles: A, B, and O. As humans are diploid, only two of these can be present in any one genotype. In other words, only two of these alleles are present at the same time in a person’s cell.

How do you calculate P and Q frequencies?

To determine q, which is the frequency of the recessive allele in the population, simply take the square root of q2 which works out to be 0.632 (i.e. 0.632 x 0.632 = 0.4). So, q = 0.63. Since p + q = 1, then p must be 1 – 0.63 = 0.37.

What protein does ABO code for?

A cell-specific regulatory region of the human ABO blood group gene regulates the neighborhood gene encoding odorant binding protein 2B. A novel ABO allele with a 21-bp duplication identified in two unrelated European individuals with weak A expression.

How do you solve allele frequency problems?

1. Step 1: Assign the Alleles. • By convention, we use the dominant phenotype to name the alleles.
2. Step 2: Calculate q. The number of homozygous recessive individuals is q.
3. Step 3: Calculate p. Once you have q, finding p is easy!
4. Step 4: Use p and q to calculate the remaining genotypes. I always suggest that you calculate q.

How does Hardy-Weinberg calculate allele frequencies?

The frequency of genotype AA is determined by squaring the allele frequency A. The frequency of genotype Aa is determined by multiplying 2 times the frequency of A times the frequency of a. The frequency of aa is determined by squaring a. Try changing p and q to other values, ensuring only that p and q always equal 1.