What drug classification is Hemabate?
What drug classification is Hemabate?
What drug classification is Hemabate?
Hemabate belongs to a group of medications called prostaglandins. These work by causing uterine contractions.
What should you assess before giving Hemabate?
To make sure Hemabate is safe for you, tell your doctor if you have:
- high or low blood pressure;
- diabetes;
- epilepsy or other seizure disorder;
- any scarring in your uterus;
- a history of asthma; or.
- a history of heart, kidney, or liver disease.
How do you administer Hemabate?
An initial dose of 1 mL of HEMABATE Sterile Solution (containing the equivalent of 250 micrograms of carboprost) is to be administered deep in the muscle with a tuberculin syringe. Subsequent doses of 250 micrograms should be administered at 1½ to 3½ hour intervals depending on uterine response.
What do you monitor with Hemabate?
Monitor Closely (1)eluxadoline increases levels of carboprost tromethamine by decreasing metabolism. Use Caution/Monitor. Eluxadoline may increase the systemic exposure of coadministered OATP1B1 substrates. Monitor Closely (1)carboprost tromethamine increases effects of oxytocin by pharmacodynamic synergism.
What is Hemabate used for in pregnancy?
HEMABATE is indicated for the treatment of postpartum hemorrhage due to uterine atony which has not responded to conventional methods of management.
Can Hemabate be given IV?
HEMABATE STERILE SOLUTION must not be given intravenously. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. HEMABATE STERILE SOLUTION (carboprost tromethamine) is administered by deep intramuscular injection.
What is the action of Hemabate?
Carboprost (Hemabate) is a man-made oxytocic medication that mimics the action of a naturally occurring chemical called prostaglandin F2 alpha. It treats bleeding in new mothers immediately after delivery.
Why is Hemabate used?
Can you give Hemabate IV?
This drug should not be given IV as it may result in bronchospasm, hypertension, vomiting, or anaphylaxis.
How long is Hemabate at room temperature?
Hemabate · Pfizer Temperature cycling data shows the product is stable when exposed to three cycles of -20°C for 2 days and 25°C for 2 days then stored at refrigerated/ambient conditions throughout the end of the shelf life.
What is the most common side effect of Hemabate?
The most frequent adverse reactions observed are related to its contractile effect on smooth muscle. In patients studied, approximately two-thirds experienced vomiting and diarrhea, approximately one-third had nausea, one-eighth had a temperature increase greater than 2° F, and one-fourteenth experienced flushing.
When do you use Hemabate?
Hemabate is usually given between the 13th and 20th weeks of pregnancy, but may be given at other times for medical reasons. Hemabate is often used when another method of abortion has not completely emptied the uterus, or when a complication of pregnancy would cause the baby to be born too early to survive.
What are the indications and usage of Hemabate?
Indications and Usage for Hemabate. Studies have shown that in such cases, the use of Hemabate has resulted in satisfactory control of hemorrhage, although it is unclear whether or not ongoing or delayed effects of previously administered ecbolic agents have contributed to the outcome. In a high proportion of cases,…
Is Hemabate safe to take short term?
There is no evidence that short term administration of Hemabate Sterile Solution can cause similar bone effects. In patients with a history of asthma, hypo- or hypertension, cardiovascular, renal, or hepatic disease, anemia, jaundice, diabetes, or epilepsy, Hemabate should be used cautiously.
What is the chemical name of the active ingredient in Hemabate?
Carboprost tromethamine is the established name for the active ingredient in Hemabate. Four other chemical names are: (15S)-15-methyl prostaglandin F2α tromethamine salt 7-(3α,5α-dihydroxy-2ß-[(3S)-3-hydroxy-3-methyl-trans-1-octenyl]-1α-cyclopentyl]-cis-5-heptenoic acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol
What are the contraindications for Hemabate?
In patients with a history of asthma, hypo- or hypertension, cardiovascular, renal, or hepatic disease, anemia, jaundice, diabetes, or epilepsy, Hemabate should be used cautiously. As with any oxytocic agent, Hemabate should be used with caution in patients with compromised (scarred) uteri.