What is the primary reason for monitoring serum vancomycin?
What is the primary reason for monitoring serum vancomycin?
What is the primary reason for monitoring serum vancomycin?
Vancomycin can also be given before certain surgeries to prevent an infection. Monitoring the level of vancomycin is important because its effectiveness relies on keeping blood levels above a minimum concentration for the entire duration of therapy (also referred to as total drug exposure).
What is a Vanco trough?
When a person takes a dose of vancomycin, the amount in the blood rises for a period of time, peaks, and then begins to fall, usually reaching its lowest level, or trough, just before the next dose. The next dose is timed to coincide with the falling concentration of the drug in the blood.
When should I order vancomycin trough?
Trough: just before 4th dose of a new regimen (prior to 3rd dose for dosing intervals ≥ 24 hours or changing renal function) – Trough levels should be obtained within 30 minutes before the next scheduled dose. – Weekly vancomycin levels should be obtained for long-term vancomycin use with stable renal function.
How do you collect vancomycin trough?
Vancomycin, Total – Collect the Peak specimen 1-2 hours after completion of a 60 minute IV infusion and Collect the Trough specimen just before administering next dose.
What causes high vancomycin trough levels?
Several risk factors have been identified for VIN, which high trough vancomycin level (especially >20 mg/L) or doses (>4 g/day), concomitant use of nephrotoxic agents, prolonged therapy (more than 7 days), and admission to an intensive care unit (especially prolonged stay) are the most common ones (1-4, 14).
What is the purpose of obtaining a trough level?
To adequately evaluate the appropriate dosage levels of many drugs, the collection and testing of specimens for trough and peak levels is necessary. The trough level is the lowest concentration in the patient’s bloodstream, therefore, the specimen should be collected just prior to administration of the drug.
How long is Vanco trough good for?
Stability Requirements
| Temperature | Period |
|---|---|
| Room temperature | 3 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
| Freeze/thaw cycles | Stable x3 |
Do you refrigerate Vanco trough?
Refrigerated (preferred) or frozen. Specimen stability: Room temperature: 48 hours.
What is Vanco peak and trough?
Vancomycin is an antibiotic drug used to treat serious, life-threatening infections by gram-positive bacteria that are resistant to less-toxic agents. The reference range for vancomycin trough levels is 5-15 mcg/mL. The reference range for vancomycin peak levels is 20-40 mcg/mL.
What is trough concentration pharmacokinetics?
Pharmacokinetic definitions Trough concentration: the concentration of drug in the blood immediately before the next dose is administered, although this does not necessarily represent the lowest concentration during a dosing interval.